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      The Medical Thread.

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      BKLFC
      • Forum Emlyn Hughes
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      The Medical Thread.
      Mar 03, 2014 04:35:58 am
      Hi everyone.
      I have never started a post, so this is my first and hope to get a good response.
      There are many Reds all over the world who have some medical issues minor or major.
      Recently BillyTheRed is had a bronchoscopy on Monday. I hope Bill keeps us updated on his result and health cos this would also help other reds facing similar problems.
      likewise, WhatAHitSon dad is undergoing chemo. Thee is a certain cannibdol oil you can place under your tongue. It has rave reviews in some states in USA. maybe there is a centre in where you are from that may help you obtain this drug. This is good because you don't need to smoke and has no side effects.
      Hope you can all share your experiences.

      « Last Edit: Mar 03, 2014 05:14:00 am by BKLFC, Reason: NA »
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #1: Mar 04, 2014 01:22:31 pm
      Just checked in and glad Reds from all over the world are doing good. Or either they haven't seen this thread  ;)
      Please take time to watch this. It could be the problem for pain to your wife, girlfriend, daughter and help in spreading the awareness.

      http://endometriosis.org/news/support-awareness/the-big-bad-wolf-of-endometriosis-raising-awareness-through-ted/

      3rd- 9th March Endometerosis Awarness Week

      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #2: Mar 08, 2014 06:11:23 am
      How on earth did the FA Medical team not find a hair line fracture in Jack Whilshire. Assuming that the FA would use a top top radiologist? Either they wanted him misdiagnosed or that medical team needs to be replaced.
      Just goes to show that choosing a top notch expert is crucial even if it means waiting it out a bit due to insurance issues, health benefits, or getting a better referral center.
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #3: Mar 13, 2014 01:23:14 pm
      Today is World Kidney Day. Please check if your local community is organizing any free check ups. When 90% kidney has been damaged, it shows no symptoms at all. Urine, blood test, key to diagnose and fight off Chronic Kidney Disease (CKD).
      BKLFC
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      Re: The Medical Thread.
      Reply #4: Mar 21, 2014 09:23:39 am
      Here's an article written by me and my wifey
      My Misdiagnosed Story

      For all you women and couples having infertility problems and Pregnancy issues, this article may give you some help.
      After being undiagnosed for 2 years in Kathmandu and suffering immense pain, my husband and I finally went to Delhi for a diagnostic laproscopy and hysterscopy with chromotubation. After surgery and rest we were thankful that I got diagnosed. But the diagnosis I had was Endometerosis and this was the reason for infertility and pain. She gave Lupride injections to suppress the endometerosis and we tried to conceive through the normal way and also IUI, which both ultimately failed.
      By now my endo was making a major comeback and by knowing that Pregnacy suppresses the Endometerosis and that it's such a disease that it can make you completely infertile we went to Kolkata for IVF treatment. Many hormonal injections and medicines later I was finally ready for egg collection. the process went fine but since my case was unique, I had to wait a whole month for my Frozen Embryo Tranfer day and again more medicines and USG to make my endometerial lining perfect for implantation.
      Finally after my FET we waited for our Beta HCG blood report. Boom! I was pregnant. We were so happy and we returned to Kathmandu with the good news.
      My first USG after 4 weeks FET date showed a gestational sac and yolk sac. My second USG I opted for Trans vaginal USG showed same thing but no heart beat. 2 weeks later same result but now the doctors are advising abortion surgically. A week later I decide to get a 2nd opinion and was told it was a Blighted Ovum. I was devastated and we mourned the loss of our baby.
      With my medical condition, I did not want to have a Blighted Ovum in my CV, as this opens a whole can of worms relating to chromosomal health of the embies. The testing for this is very expensive and highly doubt they have the facility to test it here in Nepal. In India my research points to this test being banned as it relates to gender testing, that's why the drs in India try to go around this by collecting maximum eggs during egg collection whereas in some western countries they only take one.
      So a final USG was scheduled, not in the hope that we would hear a heart beat as we knew it was not to be this time, with an independent radiologist in a top centre in Kathmandu. and rightly so there it was the calcified remains of a yolk sac. So my proper diagnosis was a missed abortion.
      There have been cases where after abortion, fetus has been found so you do need a top radiologist to make sure you are not misdiagnosed during pregnancy and always find the best team as your care givers.
      take care all moms to be in the first Tremester, as this has the highest rate for miscarriages. exercise moderately, eat healthy and take lots of rest.
      Shabs
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      Re: The Medical Thread.
      Reply #5: Mar 21, 2014 03:52:07 pm
      My lower back is killing me, was taking down a Chimney wall in the house using a large hammer drill, lost my balance on the ladder & hey presto!.

      Re aggravated it again 2days ago.
      BKLFC
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      Re: The Medical Thread.
      Reply #6: Mar 21, 2014 04:49:09 pm
      Shanbs, how long ago did you have that fall from the ladder? Better get an x-Ray done to confirm there's no damage.
      Shabs
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      Re: The Medical Thread.
      Reply #7: Mar 21, 2014 05:04:53 pm
      Shanbs, how long ago did you have that fall from the ladder? Better get an x-Ray done to confirm there's no damage.

      No fall buddy, just lost my balance as I went through a void in the chimney applying too much pressure, lost my balance on the ladder by moving forward but the weight of the hammer drill pulled me down and across.


      Sorry to read about the loss you and the wife went through mate with her pregnancy.

      My sister has tried for over 5 years to have a Child but the news was not good for her, she was told she would never conceive, husband & wife tried all treatments but failed & were then advised to take an egg donor, after giving the idea some thought they decided to go for it.

      She had arranged to meet the doctor performing the op in Barcelona, that's were the egg donor would come from,after arriving in Barcelona she was given some test with one being a pregnancy test! guess what the doctor came back into the room and broke the news she thought she would never hear, she was pregnant & would not need a donor.

      Life throws many obstacles at us to test us I guess, I remember when me & the wife were trying for a child, she miscarried our first one, she thought it was the end of the world as we were trying for 8 years, few months later she was pregnant & we have 3 little boys now.

      Always have hope, never give up, I hope & pray you and your wife find happiness in children you receive.
      BKLFC
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      Re: The Medical Thread.
      Reply #8: Mar 22, 2014 04:22:49 am
      Still get your back checked out tho, Shabs. That's a good descriptive write in your fall. Lucky you didn't smash your head, break a neck or the drill didn't drill into you.

      Thanks a lot for posting and sharing and am sooo happy to read about your sister.
      Best
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #9: Mar 22, 2014 05:16:34 am
      I am glad this thread is getting some views and hope my posts can be discussed or helpful to members and guests.

      Here's a write up of my own misdiagnosis and all you tumor or cancer waiting to be diagnosed people may find helpful.

      MY MISDIAGNOSED STORY II

      It was around 6 years back before I got married. It was late afternoon and I felt like having a snack.  I had some momo (Chinese type dumplings) and was enjoying munching away, when suddenly an intense sharp pain hit me right in my left jaw. It was unbearable pain and I sat down in agony until the pain finally subsided.
      At first I had the impression that while I was eating, my jaw must have got some sort of dislocation. The pain never returned and I was busy with my daily routines.
      It was a few months later that my Late Brother in Law, Capt. Sabin Basnet came to my house. I was in the kitchen, eating when he noticed a small lump in my left jaw and told me to get it checked out.
      Several weeks passed and I finally went to a Dentist friend who advised for digital x-Ray of my jaw. She looked at the report and said it must be that the upper joint of the jaw has slipped forward a bit. Thus, the protrusion. I took the report to an orthopedic surgeon and he said the same. He even advised me to chew gum.
      Now several years passed and am married and my brother in law has passed away in a Helicopter Rescue Operation in Solukhumbu region. I look in the mirror and the lump looks to have slowly slowly increasing in size but no pain. I hold the lump in my fingers and it's hard but can move it a little bit.
      Now, I'm trying to figure out which Dr to go and get a check up with. I decide on an ENT because of the proximity to the ear and also the air passage of my left ear goes not feel the same. The ENT does a physical examination of the lump and brushes it off to do nothing since it's not making life difficult for me. He recommends me to get a FNAC done in one his referrals. The FNAC was not painful but left a weird feeling after the doc jabbed it about 3 times to withdraw samples.
      Finally the report comes out as chronic Sialadenitis and I was happy with the report. The ent doc even said he would remove the lump with a simple procedure called a Lumpectomy. I gave it some thought because I wanted this lump (about the size of a big marble) out purely for cosmetic reasons and symmetrical face. But decided not to do anything at that moment since I had issues with my wife's ENDO as well. that time she too was not diagnosed for ENDO.
      So there I am going from hospital to hospital trying to find out the cause of pain for my wife. One family doctor, a urologist advised me to get another FNAC done because he knew the guy that did the FNAC on me and didn't think highly of him.
      Now am in Delhi, wife's recovering from her diagnostic laproscopy and I suddenly remember what the urologist said. Since I was in an international Class hospital, headed to the lab and asked to get a FNAC done. The FNAC process was a bit different, more than jabbing, I could see the guy turning something like a manual drill and it was making a "khrik-khrik" sound.The next day my wife got discharged and also had a glance at my report. It's different to my Nepal report, it's says Pleomorphic Adenoma with advise of Hystopathalogy.
      But I never got a chance to remove it there as I was too busy caring for my wife and we returned to Kathmandu. Till now am still very occupied looking after her. Need to take her for evacuation tomorrow. :(

      In concluding, if I had done the lumpectomy. The chances of my Pleomorphic Adenoma turning malignant would have increased significantly as the Lumpectomy procedure does not take out clear margins. Also if you are from a small town, it may be wiser to seek proper diagnosis in a bigger city and an institution which is renowned. Preferably your pathologist should have credentials in getting trained in the top pathology institute in your country or abroad. No matter how good the dr is if the team is bad, you suffer. A word about FNAC, these days an ultrasound guided FNA can be used. This is the safest and most correct way to do FNAC. If not done correctly it may cause spillage and spreading of the tumor or help it turn malignant. After my Partoidectomy surgery to remove my tumor, there was a satellite nodule tumor growing from the main tumor which I feel, may have been caused from the jabbing during FNAC
      I would like to write about my experience of a Partoidectomy surgery but that's for another time. But for now let's smash Cardiff and keep the momentum going forward.
      Best.

      BKLFC
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      Re: The Medical Thread.
      Reply #10: Mar 22, 2014 10:26:17 am
      BKLFC
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      Re: The Medical Thread.
      Reply #11: Mar 25, 2014 01:34:24 pm
      Ladies and Gentleman, kindly let me present to you the revolutionary System of FUSE Full Spectrum Endoscopy.
      Please see the video and get insight in this latest technology. I am absolutely raving about this god send device to detect problems in the lower GI region.
      Please check it out and check out if a hospital around you has this.
      https://vimeo.com/66772129

      It has a great question answers as well, where you can see many more videos of this Endoscope, such as https://vimeo.com/87687216

      Enjoy the videos and hope that all of you are able to get the best diagnosis, whatever your health issues, God Bless.

      Shabs
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      Re: The Medical Thread.
      Reply #12: Mar 25, 2014 01:38:38 pm
      BKLFC, are you a medical student or is the wife?.
      BKLFC
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      Re: The Medical Thread.
      Reply #13: Mar 25, 2014 01:45:38 pm
      Shabs, hi again.
      No, neither are med students. Getting married and both having medical issues. It just gave me another perspective to life. Getting involved with this test and that really made me realize you need to be on top of your game. Otherwise it's lights out. Just hoping that my post may help a RED or if someone is out there that is seeking answers and this thread may help them.
      One positives from all this experience is that it's been one hell of a learning curve.
      Shabs
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      Re: The Medical Thread.
      Reply #14: Mar 25, 2014 01:52:31 pm
      Shabs, hi again.
      No, neither are med students. Getting married and both having medical issues. It just gave me another perspective to life. Getting involved with this test and that really made me realize you need to be on top of your game. Otherwise it's lights out. Just hoping that my post may help a RED or if someone is out there that is seeking answers and this thread may help them.
      One positives from all this experience is that it's been one hell of a learning curve.

      All good buddy, nothing wrong with being prepared or even having knowledge of certain issues which can help you further down the line, as they say prevention is better than a cure.

      CORNISH
      • Forum David Johnson
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      Re: The Medical Thread.
      Reply #15: Mar 25, 2014 11:27:26 pm
      I m waiting to  have my very  enlarged spleen removed (the sooner the better) to  potentially  save my life. I have blood clots and also  suffer from severe portal hypertension and very  large and eventually lethal esophageal varices(varicose veins).They  are going to  burst  sometime in the not  too  distant  future and i will 100 % guaranteed bleed to  death  in a matter of minutes.
      The problem is my spleen is filling the varices with blood and they  are fit  to  bursting.If i have my spleen removed, no more blood can go into the varices and their " food source" is gone and they will quickly shrink and eventually disappear getting rid of the danger of me bleeding to  death.
      The success rate of me surviving the  splenectomy operation(spleen removal) for my condition is over 85 % ........................ .................

      IF my blood clots behave and stay  where they  are and dont  move to  where the doctors dont  want them  to  go.If they move, i will die.
      catch 22 , but not having the op is not an option and have to hope the clots behave themselves.
      If i  survive  i will have to  take anti biotics every day  for life and will still be prone to illnesses and infections that  wouldnt  normally  affect  people with a working spleen.
      Apart  from that  though im as fit  as a butchers dog. LOL.
      sorry  for the long post.
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #16: Mar 26, 2014 03:14:44 am
      Cornish, nice communicating with you.
      Sorry to hear that you are going through such a hard time.
      But at least the success is over 85% for a splenectomy.
      Similar stats to my Partoidectomy, not in terms of surviving the surgery but for the tumor to be B9. So try and stay positive and not worry too much. Try and channel all the negative energy into doing things you have been missing out on.
      I am not aware of insurance procedures and NHS services in the UK if you are from there. But from what I have heard it takes ages for all the processing and so forth.
      When do you plan to have your surgery?
      The sooner the better IMO. So maybe trying to push your surgery date nearer would be a good idea. Or if you could get a referral to a better hospital and a highly experienced surgeon specializing in splenctomies the better.
      You will be in my prayers.
      Best.
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #17: Mar 26, 2014 03:56:58 am
      Cornish thought this may be of interest to you.
      Drug shrinks spleens, improves quality of life, relieves symptoms in bone marrow disease
      http://www.mdanderson.org/newsroom/news-releases/2009/jak2-inhibitor-demonstrates-effective-durable-control-of-myelofibrosis.html
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #18: Mar 28, 2014 06:51:47 am
      Folks! It's Colon Cancer Awareness month. It's the 2nd highest cause of death by cancer in the USA. How many of you have had a screening? Please all get a screening done. It can show pre cancerous polyps which can be removed before turning cancerous. All the best!
      CORNISH
      • Forum David Johnson
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      Re: The Medical Thread.
      Reply #19: Mar 28, 2014 10:35:31 pm
      Having my immunisation injections on wednesday morning
      HIB , pneumonia coccal and mennigcoccal.
      Just waiting for a date for the OP now, will be in the next  month i reckon(hope).
      minimum of 2 months off work (might drag it out an extra week or 4 ) and then probably 6 months to  get  back  to  decent level of fitness and hopefully a return back to the gym and restriction lifted by the docs on how far  and fast  i can walk.
      new challenges to meet but ive proved the docs wrong by  still being alive 4 years after i got ill and they  gave me 2 days to  live so bring it on.

      Cheers for your words BKLFC.
      Good luck  to  you  and the missus.
      Shabs
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      Re: The Medical Thread.
      Reply #20: Apr 02, 2014 10:58:57 am
      Just back from the consultation with the Chiropractor, analysis, slipped disc :(
      HScRed1
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      Re: The Medical Thread.
      Reply #21: Apr 02, 2014 05:55:44 pm
      Just back from the consultation with the Chiropractor, analysis, slipped disc :(

      That does not sound good mate, all the best with the rehab.

      BTW if anybody has got any advice on Achilles tendinitiis  it would be appreciated, been suffering for over 6 months, tried the eccentric heel drops in fact still doing them regularly but just cant shift it. Maybe time to put up the five a side trainers for good.
      BKLFC
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      Re: The Medical Thread.
      Reply #22: Apr 04, 2014 07:03:21 pm
      Shabs, am glad you decided to get it checked out and got diagnosed. Make sure you ask your dr what to avoid and what to do. Speedy recovery to you mate.
      BKLFC
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      Re: The Medical Thread.
      Reply #23: Apr 04, 2014 07:09:49 pm
      HScRed HI!
      How old are you? IMO you should do some research on surgery options if you continue to wish to play footie. Otherwise, exercises with minimal stress to the tendon would be another option to stay fit. Have you visited an Ortho dr? Please do get a professional opinion and keep us posted.
      BKLFC
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      Re: The Medical Thread.
      Reply #24: Apr 04, 2014 07:27:11 pm
      To add HScRed, 6 months is a long time for it not to heal. So guessing from the duration of your pain, you have used the wait and watch approach.
      Make sure that you have not ruptured it mate by getting a diagnosis. You will get professional advise from them. Ask them about Orthotic devices. A shoe insert or wedge that slightly elevates your heel. It can relieve strain on the tendon and provide a cushion that lessens the amount of force exerted on your Achilles tendon. Ask them about all the exercises as well. Surgery should be the option if all else fails. So make sure you research a top surgeon and his team as this surgery has complications such as nerve damage or infection. But a highly experienced team should see it through with flying colors.
      BKLFC
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      Re: The Medical Thread.
      Reply #25: Apr 04, 2014 07:30:29 pm
      Cornish, you have been in my thoughts and prayers. I hope that your treatment plan is moving per schedule.
      AlexLFC95
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      Re: The Medical Thread.
      Reply #26: Apr 04, 2014 07:45:08 pm
      Anyone ever had a catheter before? Got one in until Monday, finding it very tough to deal with the pain
      BKLFC
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      Re: The Medical Thread.
      Reply #27: Apr 04, 2014 08:35:04 pm
      AlexLFC, you mean the thingy they put in your hand area to inject medicines and stuff?
      If it is, I applied little volini gel to the area for some relief. Sorry to hear that you are going through this difficulty. Check with your dr if you can have it removed earlier. I wanted to get mine out before I got discharged but the nurses insisted I keep it on. Ended up not having to be injected the next day as I got discharged with oral meds.
      If it continues to be a problem please check with your dr that it has not got infected. I highly doubt this is it the problem but rather it being there so long is causing the pain and uncomfortableness.
      But you never mentioned where your catheter is located. Some even have it to help pass urine. Get well soon.
      HScRed1
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      Re: The Medical Thread.
      Reply #28: Apr 04, 2014 10:21:31 pm
      To add HScRed, 6 months is a long time for it not to heal. So guessing from the duration of your pain, you have used the wait and watch approach.
      Make sure that you have not ruptured it mate by getting a diagnosis. You will get professional advise from them. Ask them about Orthotic devices. A shoe insert or wedge that slightly elevates your heel. It can relieve strain on the tendon and provide a cushion that lessens the amount of force exerted on your Achilles tendon. Ask them about all the exercises as well. Surgery should be the option if all else fails. So make sure you research a top surgeon and his team as this surgery has complications such as nerve damage or infection. But a highly experienced team should see it through with flying colors.

      Don't fancy surgery mate, I have done plenty of research and followed the Alfredson paper(peer reviewed as the most effective way of recovering from tendinopathy).

      Just thought if anybody else had the same issues maybe there was something I had missed in the exercises and rehab.

      BTW read an article recently that all these type of problems arise from the fact that in the modern age with cushioned heels, extra comfort soles etc this is all alien and unnatural to the way we have been designed to run and the cause if many injuries.


      BKLFC
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      Re: The Medical Thread.
      Reply #29: Apr 05, 2014 04:09:50 am
      HScRed,
      You should give surgery some thought as it seems the most effective way (Alfredson Paper) is not working for you. While your research on your condition is a great idea, you have to keep in mind that what you read in the internet sounds good, it may not be the right option for you.
      So if you haven't already been to an Ortho Dr or got an MRI for diagnosis, I would seek a professional appointment ASAP.
      Please look for friends and families who have had surgery for your type of problems. I am sure they will help you ease your fear on surgery. You should keep your options open IMO.
      TheShanklyGates
      • Forum Ian St John
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      Re: The Medical Thread.
      Reply #30: Apr 09, 2014 03:36:34 am
      Anyone ever had a catheter before? Got one in until Monday, finding it very tough to deal with the pain

      I've had one in a couple times. One of the most painful and uncomfortable things ive had. The only way I find that limits the pain and discomfort is little movement. I know its not much help but its all I can say.


      I've just came across this thread and thought I'd write my story if that's ok with everyone.
      I was born with a complicated and rare version of a  left ventricular septal heart defect which only 3 doctors in the country understand. In basic terms a 'regular' heart has 2 ventricles which sends the blood around the body in a figure of eight but I only have 1 ventricle and when I was only weeks old they had to remodel my circulation to go in a circle. It stops me from ever working but that's something I'm now fine with but when I was younger I hated it. Like I said when I weeks old and then a few months old I had 2 operations which even to this day I can never remember the name of. That was me up until I was 12 when I had open heart surgery and was put on warfarin for life. It affects my everyday life in many ways but most of all my mobility or lack of and the best way to describe it is a person with a regular walking my heart is doing the work of a slight jog,for me to jog its doing the work of a regular heart running and so on. I have oxygen sats of 85-88% instead of a typical 98-100% but after living with it for 25 years I know how to adjust my life to it. I try and not let change my life so much,I manage to sometimes get out for the day and I've been tattooed plenty times. I will probably need further surgery in years to come but for now I'm in as good health as I can be and only having to attend hospital every 6 months. Thanks to anyone that read and I hope I didn't bore you too much.
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #31: Apr 09, 2014 08:02:52 am
      Hello SuarezsRightFoot,
      No! You did not bore me with your medical story. Thank you for giving a bump to this thread. The problem you have with your heart seems very rare indeed. Which country are you from? Are the only 3 Drs that know about your condition from the same team or you see them as individuals? What is warfarin?
      On a positive note, glad you are getting regular check up as this seems the way to go.
      Please have a look at this videos which may make you contemplate getting another opinion from another country with more experience than your three Drs. Don't get me wrong your drs may be the best but I would love it if you could find finance to visit a more specialist center to get a look at it from another perspective.

       'You know what, this all sounds complicated, and it is, but I've done this a thousand times, and we've seen every curve ball -- we know what we're working with here.' A quote from the dr that operated on this girl.

      Cone reconstructive definition video using the latest technique encrypted with old school surgery.

      www.youtube.com/watch?v=VeCLIjKJAwU

      www.youtube.com/watch?v=RoV1smaeyS4
      Jan 22, 2014 - Uploaded by Team Lola
      Lola is our beautiful and bright 13 year-old daughter who was born with a very rare congenital ...

      Stay healthy and keep in touch SuarezsRightFoot!

      TheShanklyGates
      • Forum Ian St John
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      Re: The Medical Thread.
      Reply #32: Apr 09, 2014 09:04:29 am
      I'm from Scotland. The 3 doctors are individual. My latest cardiologist studied my notes for 3 weeks before my first appointment. There's probably more that after studying my notes would understand but right now there's only 3 because it so complicated. Warfarin is a blood thinner.
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #33: Apr 09, 2014 10:30:53 am
      While the quality of Drs produced by Scotland is not to be sniffed at. IMHO, travelling to a bigger city or country who deals with these rare conditions more frequently should be seriously considered. If you have the money go mate. If not start saving up for now and get in touch with the bigger, advanced centres to help with cost estimation and hopefully an appointment.
      lang may yer lum reek.
      HScRed1
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      Re: The Medical Thread.
      Reply #34: Apr 10, 2014 09:03:51 pm
      While the quality of Drs produced by Scotland is not to be sniffed at. IMHO, travelling to a bigger city or country who deals with these rare conditions more frequently should be seriously considered. If you have the money go mate. If not start saving up for now and get in touch with the bigger, advanced centres to help with cost estimation and hopefully an appointment.
      lang may yer lum reek.


      With all respect what a load of sh*te.
      Britain has and does produce some of the brightest cardiology brains in the world and places like Glasgow are world renown with great links with places like the Mayo clinic, Cleveland clinic etc so if the Cardiologists in Scotland didn't know what to do they would certainly know somebody who does.
      We don't live in some small third world country.

      No offence intended.

      BKLFC
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      Re: The Medical Thread.
      Reply #35: Apr 11, 2014 08:37:25 am
      No offence taken HSCRED,☺️

      Maybe I didn't write it right or maybe it was a misunderstanding. I meant to say they produce highest quality drs but maybe needs to go to a bigger centre as there are only 3 doctors in Scotland that deals with his case.
      English isn't my first language so apologies if it offended anyone.
      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #36: May 05, 2014 06:14:30 pm
      With all respect mate what a load of sh*t we don't live in a small third world country.
      There are many people that I know who aren't too happy with the health system in the UK.
      It was in recent times that Arrow Hospital in Liverpool had a case for infection due to unsteralised surgical instruments?
      And what about the behavior in Spain in the Levante Atletico game mocking black players, a developed nation still doing this is embarrassing.
      But my job here to listen and advise or others will come to give their opinions on health.
      Today is Hand Hygeine Day. Or is this only for small third world country?
      http://www.preventcancerinfections.org/content/discover-3-steps
      Swab
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      Re: The Medical Thread.
      Reply #37: Jun 06, 2014 11:12:43 am
      Booked in for 2 weeks time for hip replacement.
      I've decided to bite the bullet and get the f**king thing done so I can get back on the golf course properly.

      They're saying I could be home the same day, but I'll wait and see.

      The good news is that I'm still fit and strong.
      The bad news is there's a lot of muscle around the area, so it might be more painful for me that it would for others.
      Approx. 6 months rehab and with luck I'll be good to go.
      Shabs
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      Re: The Medical Thread.
      Reply #38: Jun 06, 2014 11:38:52 am
      Booked in for 2 weeks time for hip replacement.
      I've decided to bite the bullet and get the f**king thing done so I can get back on the golf course properly.

      They're saying I could be home the same day, but I'll wait and see.

      The good news is that I'm still fit and strong.
      The bad news is there's a lot of muscle around the area, so it might be more painful for me that it would for others.
      Approx. 6 months rehab and with luck I'll be good to go.

      I feel as though I need one too :D I've Got this sciatic nerve trouble since I bought down that f**king chimney wall in my house, started to get pins & needles in my left foot with the hamstring & calf muscle very tight, especially in the morning, been digging out foundations,Dry mixing & running in blocks for the rear extension and not one sign of any nerve problem, only at bedtime & early dawn.
      Swab
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      Re: The Medical Thread.
      Reply #39: Jun 06, 2014 02:43:21 pm
      I feel as though I need one too :D I've Got this sciatic nerve trouble since I bought down that f**king chimney wall in my house, started to get pins & needles in my left foot with the hamstring & calf muscle very tight, especially in the morning, been digging out foundations,Dry mixing & running in blocks for the rear extension and not one sign of any nerve problem, only at bedtime & early dawn.

      Sciatica is a b***ard mate.
      Maybe get some physio to free up the nerve.
      Shabs
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      Re: The Medical Thread.
      Reply #40: Jun 06, 2014 05:04:38 pm
      Sciatica is a b***ard mate.
      Maybe get some physio to free up the nerve.

      Trying to get an appointment with a Doc at the mo, probably Wednesday I'll get to see one.

      andylfcynwa
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      Re: The Medical Thread.
      Reply #41: Jun 07, 2014 04:07:32 pm
      Trying to get an appointment with a Doc at the mo, probably Wednesday I'll get to see one.



      No point seeing your doc about sciatica he wont do f all, the only one to see for that is a physio as Swab said to free the nerve ,mind you not to put you on too much of a downer if its gone all the way down your leg it takes longer to get over should have gone when you had the first twinges in the cheeks of your ass, after thats when it travels down and fcks your hammy up ,speaking from experience that is as one who has suffered with it on and off for years , first signs for me now and its straight to the physio room cost a couple of quid but god damn it its worth it,

      Just out of curiosity whats this dry mixing  you on about do you mean mixing by hand ,if so how on earth did you get it good enough to use to run blocks in must have been torture.
      Modify message
      andylfcynwa
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      Re: The Medical Thread.
      Reply #42: Jun 07, 2014 04:09:49 pm
      Booked in for 2 weeks time for hip replacement.
      I've decided to bite the bullet and get the f**king thing done so I can get back on the golf course properly.

      They're saying I could be home the same day, but I'll wait and see.

      The good news is that I'm still fit and strong.
      The bad news is there's a lot of muscle around the area, so it might be more painful for me that it would for others.
      Approx. 6 months rehab and with luck I'll be good to go.

      You be ok my Auntie had two hips replaced in her sixties and went on to live a very good life in fact she only died last year at the ripe old age of 99.
      Shabs
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      Re: The Medical Thread.
      Reply #43: Jun 07, 2014 07:11:22 pm
      No point seeing your doc about sciatica he wont do f all, the only one to see for that is a physio as Swab said to free the nerve ,mind you not to put you on too much of a downer if its gone all the way down your leg it takes longer to get over should have gone when you had the first twinges in the cheeks of your ass, after thats when it travels down and fcks your hammy up ,speaking from experience that is as one who has suffered with it on and off for years , first signs for me now and its straight to the physio room cost a couple of quid but god damn it its worth it,

      Just out of curiosity whats this dry mixing  you on about do you mean mixing by hand ,if so how on earth did you get it good enough to use to run blocks in must have been torture.
      Modify message


      Week the pain started I fu**ed off to a Chiropractor as I thought me disc had slipped, £400 or so later no better bit i did enjoy the lady Chiropractor all over me ;)

      As for the dry mixing, what I meant was I've got a neighbour who has an old lead pipe under his house which is leaking, so in order to get foundation in we threw in a dry mix without adding water as there was f**king plenty coming in from next door, conservative figure has us bucketing by hand 25,000 litres in 5 weeks, as for the blocks we waited the next day to lay.

      Been a nightmare especially with the weather too, been a mud bath.
      Swab
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      Re: The Medical Thread.
      Reply #44: Jun 07, 2014 07:20:15 pm
      You be ok my Auntie had two hips replaced in her sixties and went on to live a very good life in fact she only died last year at the ripe old age of 99.

      I know mate, I just don't like hospitals, and I like surgery even less, but it has to be done.
      QuicoGalante
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      Re: The Medical Thread.
      Reply #45: Jun 07, 2014 08:01:16 pm
      Week the pain started I fu**ed off to a Chiropractor as I thought me disc had slipped, £400 or so later no better bit i did enjoy the lady Chiropractor all over me ;)

      As for the dry mixing, what I meant was I've got a neighbour who has an old lead pipe under his house which is leaking, so in order to get foundation in we threw in a dry mix without adding water as there was f**king plenty coming in from next door, conservative figure has us bucketing by hand 25,000 litres in 5 weeks, as for the blocks we waited the next day to lay.

      Been a nightmare especially with the weather too, been a mud bath.

      Have that problem too, from my days of track competition. Two vertebrae crushing a nerve. Degenerative discopathy they call it.

      On and off for the past 10 years, but each episode is worse than the previous. What teally helped me is water gym and excercise. Getting the abs and lumbars stronger cause the back to be less stressed with efforts. And watch HOW you apply force. Bend knees to lift heavy objects, etc.

      Worked like a charm untill my son was born. He weights 8 kilos at four months, and no way i can control how i carry/lift him, so back pain will be on the menu soon ;)

      Good luck, and learn to live with it, its manageable
      RedPuppy
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      • Parum Rutilus Canis: Illegitimi non carborundum
      Re: The Medical Thread.
      Reply #46: Jun 07, 2014 09:18:07 pm
      I feel as though I need one too :D I've Got this sciatic nerve trouble since I bought down that f**king chimney wall in my house, started to get pins & needles in my left foot with the hamstring & calf muscle very tight, especially in the morning, been digging out foundations,Dry mixing & running in blocks for the rear extension and not one sign of any nerve problem, only at bedtime & early dawn.

      You should see your GP, to determine the cause.

      You may have a disc pinching a nerve, or it could be piriformis, which can give similar symptoms.

      An osteopath may be of benefit to give your back a good cracking. They would be able to tell if your vertebra are out of alinement.

      £400 for a chiropractor is a lot of money, I pad paid £40.00 for an assessment and full body treatment (osteopath).
      andylfcynwa
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      Re: The Medical Thread.
      Reply #47: Jun 08, 2014 10:14:07 am
      You should see your GP, to determine the cause.

      You may have a disc pinching a nerve, or it could be piriformis, which can give similar symptoms.

      An osteopath may be of benefit to give your back a good cracking. They would be able to tell if your vertebra are out of alinement.

      £400 for a chiropractor is a lot of money, I pad paid £40.00 for an assessment and full body treatment (osteopath).

      I,m with you £400 seems a hell of a lot  you can go to bupa and have an assessment  for roughly a hundred quid .
      Shabs
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      Re: The Medical Thread.
      Reply #48: Jun 08, 2014 10:49:14 am
      I,m with you £400 seems a hell of a lot  you can go to bupa and have an assessment  for roughly a hundred quid .

       About £400 for 10 sessions for cracking my back.

      Initially paid £70 for a consultation & a scan of the spine then £35 per session.
      andylfcynwa
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      Re: The Medical Thread.
      Reply #49: Jun 08, 2014 01:38:33 pm
      Well thats not to bad then.
      Swab
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      Re: The Medical Thread.
      Reply #50: Jun 18, 2014 02:03:15 pm
      Off to hospital for surgery tomorrow.
      They're hoping I'll just be in for the day and home in the evening, but we'll see.

      A long road ahead, but it has to be done.
      This is what I get for trying to do a marathon  :laugh:
      CoutinhoRed
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      Re: The Medical Thread.
      Reply #51: Jul 08, 2014 09:20:58 am
      Booked in for 2 weeks time for hip replacement.
      I've decided to bite the bullet and get the f**king thing done so I can get back on the golf course properly.

      They're saying I could be home the same day, but I'll wait and see.

      The good news is that I'm still fit and strong.
      The bad news is there's a lot of muscle around the area, so it might be more painful for me that it would for others.
      Approx. 6 months rehab and with luck I'll be good to go.

      What has your rehab been like?
      waltonl4
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      Re: The Medical Thread.
      Reply #52: Jul 09, 2014 08:28:11 pm
      I feel as though I need one too :D I've Got this sciatic nerve trouble since I bought down that f**king chimney wall in my house, started to get pins & needles in my left foot with the hamstring & calf muscle very tight, especially in the morning, been digging out foundations,Dry mixing & running in blocks for the rear extension and not one sign of any nerve problem, only at bedtime & early dawn.

      physio mate the bringers of unbelievable pain but with it relief.Get youself a Swiss ball they are magic for back problems
      Swab
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      Re: The Medical Thread.
      Reply #53: Jul 09, 2014 08:46:19 pm

      Still on crutches for now, soon as I come off them I'm on the exercise bike.
      Physio is very gentle and not putting any stress on the joint, just small gentle movements that I do during the day as well.
      The worst thing is not being able to bend or move normally, but I'll get there.
      racerx34
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      Re: The Medical Thread.
      Reply #54: Sep 25, 2014 12:47:33 pm
      So, just because I was curious, I decided to eat quite a bit of "gluten free" junk food. You know the type.
      It's marketed as a saviour even though, deep down, you know it's sh*te.

      Safe to say I haven't felt this sh*t in over 6 months.
      Chronic tiredness. Massive brain fog.
      Why the f**k did I bother?

      Here two articles to confirm what I already knew.
      Gluten Free junk food is still junk food.

      http://articles.mercola.com/sites/articles/archive/2014/08/18/gluten-free-low-carb-paleo-diet.aspx

      http://glutendude.com/celiac-rant/stop-eating-gluten-free-foods/
      Roddenberry
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      Re: The Medical Thread.
      Reply #55: Nov 19, 2014 01:59:53 am
      I've spent this year off my prescription meds.  It probably wasn't a good idea, but some of the side effects have had permanent repercussions, though coming off them may have reversed the damage, it hasn't.  I'm going to see out the year, but I'm back on them after that. My weight issues and sleep problems have both been acerbated by being clean and frankly I am seriously struggling with the pain issues.  Those who tell you that pain tells them they're alive, they're dead wrong. It makes me feel half-dead, anti-social, angry and depressed. 

      My biggest problem is, by going back on the drugs, though physically I'll feel a sh*t tonne better, they make me, trying to word this right, a little fuzzy on the mental side.  My work has been of a higher quality this year, both individually and as a team contributor, I've spotted things I probably should have noticed before and helped improve efficiency.   

      Billy1
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      Re: The Medical Thread.
      Reply #56: Nov 20, 2014 06:18:32 am
      I understand what you are going through Stuart, my doctor once prescribed me pain killers and gave me 500 at a time to take 2 tablets 3 times a day. I thought I am not going to make myself reliant on painkillers and stopped taking them, I must say I don't need them and the hour or the day is not regulated by them. Stay strong and you yourself will know if you need extra medication, cheers.
      AlwaysTheKop
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      Re: The Medical Thread.
      Reply #57: Dec 12, 2014 03:49:13 pm
      I suffer from pretty bad anxiety and possibly depression and I just needed somewhere to vent so sorry...

      Basically all my life I've been an anxious person, through school and college, I'd skip full days if I had a presentation or a one on one meeting that day. I'd get to the point that just having a conversation with someone would end up in me looking like I'd taken a swim in a lake through nervous sweats. Then after college I got a job running a machine where I presses one button in the same spot for 8 hours a day, and it totally depressed me but I didn't want to disappoint my family because they are big on the whole your worthless if your not working thing but after last Christmas it got so bad that I could no longer physically or mentally go back to that job and I quit.

      Over the past 12 months since then have been the best I remember since being a child! My anxiety pretty much vanished and I achieved a lot of personal goals such as losing almost 40 pounds and leaving my house to be social, I used to be scared of going to the supermarket believe it or not...

      During this year I've been unemployed I've been doing voluntary work and enjoying life while applying for jobs for Universal Credit and this month I heard back from Saintsbury's and my new way of life involved no fear so I blitzed the interview and even did well in the group sessions during the induction which if you told me a year ago I'd be standing in front of a group of strangers speaking confidently I'd have laughed...

      But after the induction I spent two hours on the shop floor and all that anxiety I used to feel came rushing back and hit me like a ton of bricks and since then I haven't slept and my body has been aching!

      I really don't want to go back to the person I was over a year ago.... where I was afraid to leave the house other than to work... I'm disappointed in myself because I'm already thinking about quitting and I haven't even done a full day but my anxiety is crippling!

      Today all I've done for my day off is search the internet about anxiety and that is exactly what I used to do while working for those 5 years on my time off...

      I don't know if I'm ready to work and that maybe I need to finally get my anxiety/depression looked at by a professional, but I don't want to disappoint people and appear to be a lazy person, because I'm not, and anybody that knows me would say the same.

      I just don't want everything I've accomplished this year to go to waste... like the weight loss, the daily exercise (I've skipped swimming today) and just nkt feeling anxious every second of the day....

      /rant over.
      racerx34
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      Re: The Medical Thread.
      Reply #58: Dec 12, 2014 04:44:00 pm
      I suffer from pretty bad anxiety and possibly depression and I just needed somewhere to vent so sorry...

      Basically all my life I've been an anxious person, through school and college, I'd skip full days if I had a presentation or a one on one meeting that day. I'd get to the point that just having a conversation with someone would end up in me looking like I'd taken a swim in a lake through nervous sweats. Then after college I got a job running a machine where I presses one button in the same spot for 8 hours a day, and it totally depressed me but I didn't want to disappoint my family because they are big on the whole your worthless if your not working thing but after last Christmas it got so bad that I could no longer physically or mentally go back to that job and I quit.

      Over the past 12 months since then have been the best I remember since being a child! My anxiety pretty much vanished and I achieved a lot of personal goals such as losing almost 40 pounds and leaving my house to be social, I used to be scared of going to the supermarket believe it or not...

      During this year I've been unemployed I've been doing voluntary work and enjoying life while applying for jobs for Universal Credit and this month I heard back from Saintsbury's and my new way of life involved no fear so I blitzed the interview and even did well in the group sessions during the induction which if you told me a year ago I'd be standing in front of a group of strangers speaking confidently I'd have laughed...

      But after the induction I spent two hours on the shop floor and all that anxiety I used to feel came rushing back and hit me like a ton of bricks and since then I haven't slept and my body has been aching!

      I really don't want to go back to the person I was over a year ago.... where I was afraid to leave the house other than to work... I'm disappointed in myself because I'm already thinking about quitting and I haven't even done a full day but my anxiety is crippling!

      Today all I've done for my day off is search the internet about anxiety and that is exactly what I used to do while working for those 5 years on my time off...

      I don't know if I'm ready to work and that maybe I need to finally get my anxiety/depression looked at by a professional, but I don't want to disappoint people and appear to be a lazy person, because I'm not, and anybody that knows me would say the same.

      I just don't want everything I've accomplished this year to go to waste... like the weight loss, the daily exercise (I've skipped swimming today) and just nkt feeling anxious every second of the day....

      /rant over.

      You tried going for a run or taking up some form of exercise?
      AlwaysTheKop
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      Re: The Medical Thread.
      Reply #59: Dec 12, 2014 04:54:00 pm
      You tried going for a run or taking up some form of exercise?

      I've been exercising all year, I took up swimming and gym aswell as walking everywhere within an hour range instead of taking the bus and lost 3 stone since January, but knowing I have to go to work the next day zaps every single bit of energy I have and makes all that stuff, which I've been enjoying, seem like a chore now.
      Bier
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      Re: The Medical Thread.
      Reply #60: Dec 12, 2014 04:59:14 pm
      AlwaysTheKop, you should do what's best for yourself mate, don't worry about what others think or if you might dissapoint them, that's waisted energy. I know that's easier said than done in your situation, it's certainly not a feeling you can just shut down, but you should try not to factor that into your decision making. Also, get professional help. If anxiety plays such a big role in your life then maybe a professional can help you learn to deal with it in a better way.
      racerx34
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      Re: The Medical Thread.
      Reply #61: Dec 12, 2014 09:04:30 pm
      I've been exercising all year, I took up swimming and gym aswell as walking everywhere within an hour range instead of taking the bus and lost 3 stone since January, but knowing I have to go to work the next day zaps every single bit of energy I have and makes all that stuff, which I've been enjoying, seem like a chore now.

      I know the feeling. World's greatest irony that you have to be at your strongest when you are at your weakest.

      Try and look for positive things in what you are doing. Easier Saud than done, I know.

      Good luck.
      Shabs
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      Re: The Medical Thread.
      Reply #62: Dec 12, 2014 09:56:41 pm
      I suffer from pretty bad anxiety and possibly depression and I just needed somewhere to vent so sorry...

      Basically all my life I've been an anxious person, through school and college, I'd skip full days if I had a presentation or a one on one meeting that day. I'd get to the point that just having a conversation with someone would end up in me looking like I'd taken a swim in a lake through nervous sweats. Then after college I got a job running a machine where I presses one button in the same spot for 8 hours a day, and it totally depressed me but I didn't want to disappoint my family because they are big on the whole your worthless if your not working thing but after last Christmas it got so bad that I could no longer physically or mentally go back to that job and I quit.

      Over the past 12 months since then have been the best I remember since being a child! My anxiety pretty much vanished and I achieved a lot of personal goals such as losing almost 40 pounds and leaving my house to be social, I used to be scared of going to the supermarket believe it or not...

      During this year I've been unemployed I've been doing voluntary work and enjoying life while applying for jobs for Universal Credit and this month I heard back from Saintsbury's and my new way of life involved no fear so I blitzed the interview and even did well in the group sessions during the induction which if you told me a year ago I'd be standing in front of a group of strangers speaking confidently I'd have laughed...

      But after the induction I spent two hours on the shop floor and all that anxiety I used to feel came rushing back and hit me like a ton of bricks and since then I haven't slept and my body has been aching!

      I really don't want to go back to the person I was over a year ago.... where I was afraid to leave the house other than to work... I'm disappointed in myself because I'm already thinking about quitting and I haven't even done a full day but my anxiety is crippling!

      Today all I've done for my day off is search the internet about anxiety and that is exactly what I used to do while working for those 5 years on my time off...

      I don't know if I'm ready to work and that maybe I need to finally get my anxiety/depression looked at by a professional, but I don't want to disappoint people and appear to be a lazy person, because I'm not, and anybody that knows me would say the same.

      I just don't want everything I've accomplished this year to go to waste... like the weight loss, the daily exercise (I've skipped swimming today) and just nkt feeling anxious every second of the day....

      /rant over.

      Have you tried meditation?, I know it helps as I've suffered in the past from anxiety & panic attacks.

      BKLFC
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      Re: The Medical Thread.
      Reply #63: Jan 01, 2015 09:56:55 am
      Dear Cornish!
      happy new year! So did you get the op done. Here is some info which may interest you regarding your spleen for alternative medicine when all else doesn't seem to work.

      Abstract
      Specialized B cells residing in the splenic marginal zone (MZ) continuously survey the blood for antigens and are important for immunity to systemic infections. However, the cues that uniquely attract cells to the MZ have not been defined. Previous work demonstrated that mice deficient in cannabinoid receptor 2 (CB2) have decreased numbers of MZ B cells but it has been unclear whether CB2 regulates MZ B cell development or positioning. We show that MZ B cells are highly responsive to the CB2 ligand 2-arachidonylglycerol (2-AG) and that CB2 antagonism rapidly displaces small numbers of MZ B cells to the blood. Antagonism for longer durations depletes MZ B cells from the spleen. In mice deficient in sphingosine-1-phosphate receptor function, CB2 antagonism causes MZ B cell displacement into follicles. Moreover, CB2 overexpression is sufficient to position B cells to the splenic MZ. These findings establish a role for CB2 in guiding B cells to the MZ and in preventing their loss to the blood. As a consequence of their MZ B cell deficiency, CB2-deficient mice have reduced numbers of CD1d-high B cells. We show that CB2 deficiency results in diminished humoral responses to a CD1d-restricted systemic antigen.

      Source: Cannabinoid receptor 2 positions and retains margi... [J Exp Med. 2011] - PubMed - NCBI





      BKLFC
      • Forum Emlyn Hughes
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      Re: The Medical Thread.
      Reply #64: Jan 01, 2015 09:58:43 am
      A Cyclooxygenase Metabolite Of Anandamide Causes Inhibition Of Interleukin-2
      Abstract

      Arachidonyl ethanolamine, which is commonly known as anandamide, was the first endogenous compound to be identified that binds to the cannabinoid receptors. Anandamide mimics many of the physiological effects of Δ9-tetrahydrocannabinol (Δ9-THC), including hypothermia, antinociception, immobility, catalepsy, and immune modulation. In the present studies, we show that anandamide caused a concentration-dependent inhibition of interleukin-2 in primary splenocytes. The CB1 and CB2 antagonists, SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorphenyl)-4-methyl-H-pyrazole-3 carboxyamidehydrochlorid e] and SR144528 [N-[(1S)-endo-1,3,3,-trimethylbicyclo[2,2,1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide], when used in combination, did not antagonize the inhibition of interleukin-2 by anandamide. Additionally, neither UCM707 [N-(3-furanylmethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide], the inhibitor of the putative anandamide membrane transporter (AMT), nor methyl arachidonoyl fluorophosphonate (MAFP), the inhibitor of fatty acid amidohydrolase (FAAH), were able to affect the inhibitory activity of anandamide upon interleukin-2. Interestingly, arachidonic acid caused a concentration-dependent inhibition of interleukin-2 secretion (IC50 = 10.3 μM), which was similar to that of structurally related anandamide (IC50 = 11.4 μM). The inhibition of interleukin-2 by anandamide and arachidonic acid was partially reversed by pretreatment with the nonspecific cyclooxygenase inhibitors, flurbiprofen and piroxicam. Moreover, NS398 [N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide], a cyclooxygenase-2-specific inhibitor, also attenuated the inhibitory effects of anandamide and arachidonic acid upon interleukin-2 secretion. Finally, pretreatment with a peroxisome proliferator-activated receptor γ (PPARγ)-specific antagonist, T0070907 [2-chloro-5-nitro-N-4-pyridinyl-benzamide], partially antagonized anandamide-mediated suppression of IL-2 secretion. Collectively, the aforementioned studies suggest that inhibition of interleukin-2 secretion by anandamide is independent of CB1/CB2 and the AMT/FAAH system. Additionally, these studies also suggest that inhibition of interleukin-2 is mediated by a PPARγ, which is activated by a cyclooxygenase-2 metabolite of anandamide.

      Two cannabinoid receptors have been isolated and cloned to date, CB1 and CB2 (Matsuda et al., 1990; Munro et al., 1993). CB1 is widely distributed in the central nervous system but is also found in a number of other tissues (Matsuda et al., 1990). CB2 is the predominant cannabinoid receptor expressed in cells of the immune system, although CB1 is also detected in many immune cells at lower levels (Kaminski et al., 1992; Munro et al., 1993). Both receptors have seven transmembrane domains and are G-protein-coupled. CB1 and CB2 share only 44% homology, which increases to 68% when comparing only the transmembrane regions that contain the ligand-binding domains (Munro et al., 1993). Arachidonyl ethanolamine, also known as anandamide, was the first endogenous cannabinoid receptor ligand to be identified through radioligand binding analysis and was therefore termed an endocannabinoid (Devane et al., 1992).

      Recently published studies suggest that CB2 may be involved with a number of immunomodulatory effects, including inhibition of macrophage-dependent T cell activation, induction of the immunosuppressive cytokine, transforming growth factor β, in human peripheral blood lymphocytes stimulated with anti-CD3, inhibition of antigen processing by macrophages, and induction of cytokine and chemokine production in HL-60 cells (McCoy et al., 1999; Buckley et al., 2000; Derocq et al., 2000; Gardner et al., 2002). Although CB1 is typically expressed at much lower levels in immune cells than CB2, there is also evidence to suggest a role for CB1 in certain immunological effects, such as inhibition of tumor necrosis factor α and interleukin-12 in LPS-treated mice as well as induction of interleukin-6 in mouse astrocytes (Molina-Holgado et al., 1998; Smith et al., 2001). Anandamide has been shown to modulate a number of immunological responses, including inhibition of nitric oxide and cytokine production in macrophages as well as inhibition of tumor necrosis factor α and neutrophil recruitment in lipopolysaccharide-induced pulmonary inflammation in mice (Berdyshev et al., 1998; Chang et al., 2001). Whether these effects are in fact mediated through the cannabinoid receptors has yet to be rigorously examined, however.

      Anandamide can be synthesized by a variety of cell types, including neurons, RBL-2HE basophils, and J774 macrophages (Sugiura et al., 2002). It has been proposed that anandamide is rapidly inactivated by a reuptake system consisting of the anandamide membrane transporter (AMT), which transports anandamide into the cell where fatty acid amidohydrolase (FAAH) hydrolyzes anandamide into arachidonic acid and ethanolamine (Di Marzo et al., 1994). Although FAAH appears to be the primary enzyme responsible for the hydrolysis of anandamide, an acid amidase has recently been identified that is also capable of hydrolyzing anandamide (Ueda et al., 2001b). In addition to metabolism by FAAH and the acid amidase, anandamide can also be oxygenated by cyclooxygenase-2 into prostaglandin E2 ethanolamide and other cyclooxygenase products as well (Yu et al., 1997). Prostaglandin E2-ethanolamide appears to mediate physiological effects similar to those produced by prostaglandin E2 (Ross et al., 2002).

      Anandamide is well known to cause a number of immunomodulatory effects including modulation of cytokine production, but nothing to date has been published concerning the effects of anandamide upon IL-2 secretion. Moreover, previously published studies from this laboratory have shown that 2-arachidonyl glycerol, a compound that is closely related to anandamide structurally, causes inhibition of interleukin-2 production in activated T cells (Ouyang et al., 1998). The objective of the present studies was then to determine the effect of anandamide upon interleukin-2 secretion. Interleukin-2 is an autocrine/paracrine factor secreted by activated T cells, which promotes T cell proliferation. Interleukin-2 has virtually no basal level of expression but is rapidly secreted upon T cell stimulation such that it is a hallmark of T cell activation. The current studies demonstrate that anandamide causes a concentration-dependent inhibition of interleukin-2 secretion in primary splenocytes, which is independent of CB1/CB2 and involves the activation of peroxisome proliferator activated receptor γ (PPARγ) by a cyclooxygenase-2 metabolite of anandamide.

      Materials and Methods

      Reagents. Anandamide, SR141716A, and SR144528 were provided by the National Institute of Drug Abuse. UCM707, MAFP, piroxicam, NS398, and T0070907 were purchased from Cayman Chemical (Ann Arbor, MI). All other reagents were purchased from Sigma-Aldrich (St. Louis, MO) unless otherwise indicated.

      Animals and Cell Cultures. Female B6C3F1 mice, 6 weeks of age, were purchased from Charles River Breeding Laboratories (Portage, MI). On arrival, mice were randomized, transferred to plastic cages containing sawdust bedding (5 animals/cage), and quarantined for 1 week. Mice were given food (Purina Certified Laboratory Chow) and water ad libitum. Mice were not used for experimentation until their body weight was 17 to 20 g. Animal holding rooms were kept at 21-24°C and 40 to 60% relative humidity with a 12-h light/dark cycle. Spleens were isolated aseptically and made into single-cell suspensions (1 × 106 cells/ml). Cells were cultured in RPMI-1640 supplemented with 100 units/ml penicillin, 100 units/ml streptomycin, 50 μM 2-mercapoethanol, and 2% bovine calf serum.

      Interleukin-2 Protein Quantification. Splenocytes were cultured in triplicate (1 × 106 cells/ml) in 48-well culture plates (800 μl/well). The cells were pretreated with antagonist or vehicle (or not pretreated in the case of the anandamide and arachidonic acid concentration responses) for 30 min prior to treatment with either anandamide or arachidonic acid. Splenocytes were activated 30 min later with 40 nM PMA and 0.5 μM ionomycin. The supernatants were collected 24 h after stimulation, and interleukin-2 protein was quantified using a sandwich enzyme-linked immunosorbent assay (ELISA) method previously described (Kaplan et al., 2003). The interleukin-2 standard (mouse recombinant interleukin-2), purified rat anti-mouse interleukin-2 antibody, and biotinylated anti-mouse interleukin-2 antibody were purchased from BD PharMingen (San Diego, CA).

      Statistical Analysis. The mean ± S.E. was determined for each treatment group in the individual experiments. Homogeneous data were evaluated by a parametric analysis of variance (ANOVA). For those experiments with two factors, a two-way ANOVA was employed. Dunnett's two-tailed t test was used to compare treatment groups with the vehicle control when significant differences were observed (Dunnett, 1955). IC50 values were calculated from the average of four different concentration responses using Prism GraphPad software (GraphPad Software Inc., San Diego, CA).

      Results

      Anandamide Causes a Robust Inhibition of Interleukin-2 Secretion, Which Is Unaffected by Pretreatment with the CB1/CB2 Antagonists. Previous studies from our laboratory have shown that the endogenous cannabinoid, 2-AG, produced a concentration-dependent inhibition of interleukin-2 in activated T cells (Ouyang et al., 1998). In light of these findings, a similar analysis of anandamide was performed. In splenocytes activated with PMA and ionomycin, anandamide caused a concentration-dependent inhibition of interleukin-2 with an IC50 of 11.4 μM (Fig. 1). The subsequent experiments were designed to determine the mechanism by which anandamide causes inhibition of interleukin-2 with the initial studies focusing upon the cannabinoid receptors. Although CB2 is the predominant cannabinoid receptor expressed in immune cells, low levels of CB1 transcripts have been detected in many immune cells, including T cells (Galiegue et al., 1995). Therefore, the role of both CB1 and CB2 on the inhibition of interleukin-2 secretion by anandamide was evaluated. Pretreatment of primary splenocytes with the CB1 and CB2 antagonists, SR141716A and SR144528, used in combination (0.05/0.05, 0.5/0.5, and 5/5 μM), prior to treatment with anandamide (10 μM) did not attenuate anandamide-mediated inhibition of interleukin-2 secretion (Fig. 2). At the highest concentration used (5/5 μM), SR141716A and SR144528, when employed in combination in the absence of anandamide, caused inhibition of interleukin-2 secretion. Additionally, neither pretreatment with SR141716A nor SR144528 alone attenuated anandamide-mediated suppression of interleukin-2 secretion (data not shown).

      Arachidonic Acid Also Causes a Concentration-Dependent Inhibition of Interleukin-2 Secretion. Because it was unclear whether the inhibitory effect of anandamide upon interleukin-2 secretion was due to the parent molecule or a hydrolysis product of anandamide, the effect of arachidonic acid upon interleukin-2 secretion was also evaluated. Treatment of primary splenocytes with various concentrations of arachidonic acid (0.1-20 μM) caused a concentration-dependent inhibition of interleukin-2 secretion (Fig. 3). The magnitude of interleukin-2 inhibition produced by arachidonic acid was very similar to that observed with anandamide as evidenced by the calculated IC50 values: 11.4 and 10.3 μM for anandamide and arachidonic acid, respectively.

      Neither Inhibition of the AMT nor Inhibition of FAAH Attenuates Suppression of Interleukin-2 by Anandamide. Because arachidonic acid produced a concentration-responsive suppression of interleukin-2 secretion with a profile of inhibition that resembled that of anandamide, it seemed reasonable that inhibition of interleukin-2 by anandamide was mediated by arachidonic acid, which is probably formed from the hydrolysis of anandamide rather than by the parent molecule of anandamide itself. It has been postulated that the AMT may be coupled to FAAH, the chief enzyme responsible for anandamide hydrolysis, and that these two proteins represent a major mechanism for the uptake and catabolism of anandamide (Giuffrida et al., 2001). As such, the potential roles of the AMT and FAAH in anandamide-mediated interleukin-2 inhibition were studied. Pretreatment with the AMT inhibitor, UCM707, at various concentrations (1-20 μM), did not attenuate anandamide-mediated suppression of interleukin-2 secretion (Fig. 4). Prior to evaluation of the effect of the FAAH inhibitor, MAFP, upon anandamide-mediated interleukin-2 inhibition, the effect of MAFP upon interleukin-2 in the absence of anandamide was determined. MAFP caused a concentration-responsive inhibition of interleukin-2 secretion at concentrations of 5 μM and higher (data not shown). Because MAFP is also a phospholipase A2 inhibitor and previous studies from this laboratory have shown that phospholipase A2 inhibitors cause a decrease in interleukin-2 production, the inhibitory effect of MAFP upon interleukin-2 secretion was not unexpected (Ouyang and Kaminski, 1999). Based upon the afore-mentioned study, 1 μM MAFP was the maximum concentration used for subsequent experiments due to the absence of an effect upon interleukin-2 coupled with the fact that the concentration is sufficient to inhibit FAAH (IC50 = 2.5 nM). Pretreatment with a broad range of concentrations of MAFP (0.001-1 μM) did not attenuate the inhibition of IL-2 secretion by anandamide (Fig. 5).

      Suppression of Interleukin-2 Secretion by Anandamide and Arachidonic Acid Is Attenuated by the Nonspecific Cyclooxygenase Inhibitors Flurbiprofen and Piroxicam. Due to the similarity in the concentration responses of anandamide and arachidonic acid in the inhibition of interleukin-2, the role of the cyclooxygenase enzymes was investigated. Initial evaluation of concentration responses of flurbiprofen determined 50 μM to be the optimum concentration for inhibition of cyclooxygenase-1 and cyclooxygenase-2 in splenocytes (data not shown). The higher concentration of 100 μM flurbiprofen caused marked inhibition of interleukin-2 by itself, which is not surprising since flurbiprofen (in the range of 100 to 1000 μM) is known to inhibit the activation of nuclear factor κ of B cells, an important transcription factor for interleukin-2 transcription (Tegeder et al., 2001). Although 50 μM flurbiprofen caused inhibition of interleukin-2 secretion in the absence of anandamide or arachidonic acid, the inhibition was far less robust than that which was caused by 100 μM flurbiprofen and nonetheless still caused an almost complete reversal of anandamide-mediated interleukin-2 inhibition (Fig. 6A). Likewise, flurbiprofen pretreatment also significantly attenuated the suppression of interleukin-2 mediated by arachidonic acid (Fig. 6B). Similar to flurbiprofen, pretreatment of primary splenocytes with piroxicam partially attenuated the inhibitory activity of both anandamide as well as arachidonic acid upon interleukin-2 secretion (Fig. 7). Moreover, the effect of piroxicam upon anandamide-mediated suppression of interleukin-2 is concentration-dependent (Fig. 9A).

      NS398, a Cyclooxygenase-2-Specific Inhibitor, Partially Attenuated the Inhibition of IL-2 Secretion by Anandamide and Arachidonic Acid. To determine whether the inhibitory activity of anandamide and arachidonic acid upon interleukin-2 was mediated by a cyclooxygenase-1 or cyclooxygenase-2 metabolite, the ability of NS398, a cyclooxygenase-2-specific inhibitor, to attenuate suppression of interleukin-2 by anandamide and arachidonic acid was evaluated. Similar to flurbiprofen and piroxicam, NS398 also attenuated the inhibition of IL-2 secretion by anandamide and arachidonic acid (Fig. 8). In addition, the attenuation by NS398 of anandamide-mediated inhibition of IL-2 secretion is also concentration-dependent (Fig. 9B). Conversely, the cyclooxygenase-1 specific inhibitors, SC560 and FR122047, did not have an effect upon the suppression of interleukin-2 secretion by anandamide (data not shown).

      Suppression of Interleukin-2 Secretion by Anandamide Is Partially Antagonized by Pretreatment with T0070907, a PPARγ Antagonist. Because activated PPARγ has been shown to cause inhibition of interleukin-2 secretion and a number of cyclooxygenase products, such as PGD2 and 15-deoxy-Δ12,14 PGJ2, have been shown to be endogenous agonists of PPARγ; the ability of T0070907, a specific PPARγ antagonist, to antagonize inhibition of interleukin-2 secretion by anandamide was examined. Pretreatment of primary splenocytes with T0070907, at various concentrations (0.1-10 μM), caused a concentration-dependent antagonism of anandamide-mediated suppression of interleukin-2 secretion (Fig. 10). Although the highest concentration of T0070907 used (10 μM), caused inhibition of interleukin-2 in the absence of anandamide, T0070907 nevertheless still caused a significant reversal of the effects of anandamide upon interleukin-2 at this concentration.

      Discussion

      The present studies demonstrate that anandamide causes a concentration-dependent inhibition of interleukin-2 secretion. The current studies also show that suppression of interleukin-2 secretion mediated by anandamide is not attenuated by pretreatment with the cannabinoid receptor antagonists, SR141716A and SR144528, suggesting that it is independent of both CB1 and CB2. Interestingly, arachidonic acid also caused a concentration-responsive inhibition of interleukin-2, which is similar to that of anandamide. The similarity was also evident from the calculated IC50 values, which were 11.4 μM and 10.3 μM for anandamide and arachidonic acid, respectively. Although the suppression of interleukin-2 by arachidonic acid suggests that inhibition of interleukin-2 by anandamide may be mediated by a product of anandamide hydrolysis rather than the parent molecule itself, neither pretreatment with an AMT inhibitor nor a FAAH inhibitor attenuated suppression of interleukin-2 secretion by anandamide. Pretreatment with two different nonspecific cyclooxygenase inhibitors, flurbiprofen and piroxicam, partially attenuated inhibition of interleukin-2 secretion by both anandamide and arachidonic acid, suggesting a role for the cyclooxygenase enzymes. Likewise, NS398, a cyclooxygenase-2-specific inhibitor also attenuated the inhibition of interleukin-2 secretion by both anandamide and arachidonic acid, whereas the cyclooxygenase-1 specific inhibitors, SC560 and FR122047, had no effect (data not shown). In addition, T0070907, a PPARγ-specific antagonist, caused a concentration-dependent partial antagonism of anandamide-mediated inhibition of interleukin-2. Collectively, the aforementioned observations suggest that the inhibition of interleukin-2 secretion is partially mediated by PPARγ, which is activated by a cyclooxygenase-2 metabolite of anandamide.

      The concentrations of anandamide, which cause inhibition of interleukin-2 secretion, are in the low micromolar range. Although concentrations of anandamide have been detected in the nanomolar range in rat and human plasma, the local concentrations of anandamide at the various target sites have yet to be determined. Because anandamide is synthesized de novo from membrane components, it seems likely, however, that concentrations of anandamide might be quite high within the microcosms of the target regions. Measurements of anandamide are further confounded by the lability of the compound. Moreover, anandamide has generally been measured in normal healthy tissue and plasma samples, whereas these levels may differ substantially in inflamed or damaged tissues. Arachidonic acid levels, for instance, have been shown to increase into the upper micromolar range in damaged tissues (Patel et al., 2003). Furthermore, arachidonic acid mobilization has been linked to increased anandamide synthesis (Pestonjamasp and Burstein, 1998).

      Although there have been a number of effects of endocannabinoids attributed to CB1/CB2, there are also a growing number of reports of endocannabinoid activities that are independent of CB1/CB2 in keeping with the studies reported here (Smart et al., 2000, Ross et al., 2002). One potential mechanism for cannabinoid receptor-independent activity is the vanilloid receptor, VR1. VR1 is a ligand-gated cation channel that is activated by heat or capsaicin. Anandamide is a full agonist of VR1 albeit at concentrations 10 to 20 times higher than those at which it activates CB1 (Smart et al., 2000). It is notable that the VR1 agonist, capsaicin, does not cause inhibition of interleukin-2 secretion and that the VR1 antagonist, capsazepine, does not attenuate anandamide-mediated interleukin-2 inhibition (data not shown). The current study is unique because it not only demonstrates anandamide-mediated activity that is independent of CB1/CB2 and VR1, but also because it shows that the metabolism of anandamide does not always lead to the cessation of physiological effects but in certain circumstances may actually be responsible for the biological activity observed.

      There have been a number of reports that anandamide mediates arachidonic acid release from various cell types, including human peripheral blood mononuclear cells (Berdyshev et al., 1997; Di Marzo et al., 1997). Therefore, an alternative explanation for the observations of the current investigation is that anandamide causes release of arachidonic acid from the primary splenocytes. The released arachidonic acid is then subsequently metabolized into an eicosanoid, which mediates the inhibition of interleukin-2 secretion. Although the current studies do not negate the possibility that anandamide causes arachidonic acid release, the striking similarity in the concentration responses of anandamide and arachidonic acid suggests that the same moiety is responsible for the activity of both anandamide and arachidonic acid. Further studies will be needed to determine whether this is the case, however.

      The primary mechanism that has been identified for the hydrolysis of anandamide is through the enzyme FAAH. FAAH has been detected in a variety of different tissues with the highest levels found in the brain, liver, small intestine, and testes, whereas relatively low levels have been found in the spleen (Bisogno et al., 2002). Although FAAH seems to be the primary mechanism for the hydrolysis of anandamide, at least one other enzyme has been identified that hydrolyzes anandamide. Unlike FAAH, the other amidase has an optimal pH of 5, is not inhibited by MAFP, and is also reported to have a high level of activity in the spleen (Ueda et al., 2001a). Under the conditions used for the current studies, it is likely that anandamide is either hydrolyzed by the acid amidase, another amidase that has yet to be identified, or is directly metabolized by cyclooxygenase-2.

      Whereas the vast majority of research on anandamide metabolism has focused upon FAAH, there has also been considerable interest in the role of the cyclooxygenase enzymes. There are two isoforms of the cyclooxygenase enzyme, cyclooxygenase-1 and cyclooxygenase-2. Cyclooxygenase-1 is constitutively expressed in most cell types, whereas cyclooxygenase-2 expression is induced in response to a stimulus only in certain cell types (Parente and Perretti, 2003). Both cyclooxygenase enzymes have been found in most cells within the immune system, including T cells (Tilley et al., 2001). It has been reported that anandamide can bind directly to cyclooxygenase-2 and be metabolized into prostaglandin E2-ethanolamide and other products as well (Yu et al., 1997). The same studies have also demonstrated, however, that anandamide neither binds directly to nor is oxygenated by cyclooxygenase-1.

      There is evidence to support that a number of different prostanoids can cause inhibition of interleukin-2 secretion, including prostaglandin E2, 15-deoxy-Δ12,14 prostaglandin J2, and prostaglandin I2 (Marcinkiewicz and Chain, 1993; Yang et al., 2000; Harris et al., 2002). Of the aforementioned eicosanoids, 15-deoxy-Δ12,14 prostaglandin J2 (15d-PGJ2) is the most recent to be recognized to suppress interleukin-2 secretion. There has been growing interest in 15d-PGJ2 in a number of different research areas due to its identification as one of the most potent endogenous ligands of PPARγ. Structurally related to the hormone receptors, PPARs are also members of the nuclear receptor superfamily. Currently, there are three subtypes of PPARs that have been identified: PPARα, PPARδ, and PPARγ. Although the function of PPARδ remains unclear, PPARα and PPARγ have been best characterized for their roles in lipid metabolism and have only recently been discovered to also be involved with immunoregulation (Clark, 2002). Although both PPARα and PPARγ are expressed in T cells, only activated PPARγ causes an inhibition of IL-2 secretion. Physical association of activated PPARγ with the transcription factor, NFAT, appears to suppress NFAT binding to the IL-2 promoter, which is thought to be the mechanism for the decrease in interleukin-2 production by PPARγ agonists (Yang et al., 2000). Similarly, activated PPARγ has also been shown to cause decreased cytokine production in activated macrophages through direct protein-protein interaction with nuclear factor κB, a key transcription factor for a number of different cytokines (Ricote et al., 1998).

      15d-PGJ2 is produced through the sequential metabolism of arachidonic acid by cyclooxygenase and PGD synthase, followed by a series of nonenzymatic transformations (Zhang and Young, 2002). Whether 15d-PGJ2 is produced in vivo has been somewhat of a controversy; however, recent studies have identified elevated levels of 15d-PGJ2 in LPS-stimulated RAW264.7 macrophages (Shibata et al., 2002). Future studies will determine whether 15d-PGJ2 is produced in other cell types, but it is notable that both enzymes required for 15d-PGJ2 formation, cyclooxygenase and PGD synthase, are expressed in T cells. Although 15d-PGJ2 is one of the most potent activators of PPARγ, other cyclooxygenase products are also able to activate PPARγ. More studies will be needed to determine exactly which cyclooxygenase products are produced from anandamide metabolism and which are subsequently responsible for the observed inhibition of interleukin-2 production.

      Although several studies have emerged which suggest that under certain conditions activated PPARγ may cause apoptosis in activated T cells, there are also a number of studies suggesting that PPARγ activation may be protective against apoptosis or have no effect upon viability (Clark, 2002; Wang et al., 2002). Whereas the cause of the differential effects of activated PPARγ upon T cell viability is unclear, it is likely that the concentration of 15d-PGJ2, the kinetics of cell treatment, and/or the state/mode of activation may be factors. Under the specific conditions used in the present studies, there was no effect upon cellular viability. It should be noted, however, that anandamide and arachidonic acid are likely to be metabolized into a number of different products, some of which may be protective against apoptosis.

      Although in the majority of cases studied thus far the metabolism of anandamide has been associated with the cessation of its physiological activity, the present studies are significant because they show that metabolism of anandamide in certain cases may yield a biologically active product. It has been demonstrated here that the metabolism of anandamide by cyclooxygenase-2 yields a product that causes inhibition of interleukin-2 secretion through activation of PPARγ.

      Source, Graphs and Figures: A Cyclooxygenase Metabolite of Anandamide Causes Inhibition of Interleukin-2 Secretion in Murine Splenocytes
      BKLFC
      • Forum Emlyn Hughes
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      • Started Topic

      • 822 posts |
      Re: The Medical Thread.
      Reply #65: Jan 01, 2015 10:00:16 am
      Molecular Characterization Of A Peripheral Receptor For Cannabinoids
      Abstract

      The major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases of their action. Progress stemmed initially from the synthesis of potent derivatives of delta 9-THC, and more recently from the cloning of a gene encoding a G-protein-coupled receptor for cannabinoids. This receptor is expressed in the brain but not in the periphery, except for a low level in testes. It has been proposed that the nonpsychoactive effects of cannabinoids are either mediated centrally or through direct interaction with other, non-receptor proteins. Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen.

      Source: PMID:7689702 [PharmGKB]

      Please let us know how you are doing Cornish YNWA
      Mad4LFC
      • Forum Ian Callaghan
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      • 989 posts | 81 
      Re: The Medical Thread.in
      Reply #66: Jan 01, 2015 11:34:21 am
      I suffer from pretty bad anxiety and possibly depression and I just needed somewhere to vent so sorry...

      Basically all my life I've been an anxious person, through school and college, I'd skip full days if I had a presentation or a one on one meeting that day. I'd get to the point that just having a conversation with someone would end up in me looking like I'd taken a swim in a lake through nervous sweats. Then after college I got a job running a machine where I presses one button in the same spot for 8 hours a day, and it totally depressed me but I didn't want to disappoint my family because they are big on the whole your worthless if your not working thing but after last Christmas it got so bad that I could no longer physically or mentally go back to that job and I quit.

      Over the past 12 months since then have been the best I remember since being a child! My anxiety pretty much vanished and I achieved a lot of personal goals such as losing almost 40 pounds and leaving my house to be social, I used to be scared of going to the supermarket believe it or not...

      During this year I've been unemployed I've been doing voluntary work and enjoying life while applying for jobs for Universal Credit and this month I heard back from Saintsbury's and my new way of life involved no fear so I blitzed the interview and even did well in the group sessions during the induction which if you told me a year ago I'd be standing in front of a group of strangers speaking confidently I'd have laughed...

      But after the induction I spent two hours on the shop floor and all that anxiety I used to feel came rushing back and hit me like a ton of bricks and since then I haven't slept and my body has been aching!

      I really don't want to go back to the person I was over a year ago.... where I was afraid to leave the house other than to work... I'm disappointed in myself because I'm already thinking about quitting and I haven't even done a full day but my anxiety is crippling!

      Today all I've done for my day off is search the internet about anxiety and that is exactly what I used to do while working for those 5 years on my time off...

      I don't know if I'm ready to work and that maybe I need to finally get my anxiety/depression looked at by a professional, but I don't want to disappoint people and appear to be a lazy person, because I'm not, and anybody that knows me would say the same.

      I just don't want everything I've accomplished this year to go to waste... like the weight loss, the daily exercise (I've skipped swimming today) and just nkt feeling anxious every second of the day....

      /rant over.

      Mate i feel your pain and anxiety is a crippler when it attacks, in my job i went from giving evidence at the old bailey to being scared of going to the local shop and speaking to the sales staff due to one episode of anxiety. Thing is though as hard as it may seem there is only one cause of the anxiety and that is YOU nothing else. When you come to terms with this you can the take the next step and try to find a treatment that works for you.

      I have tried medication and for me that doesnt or should i say didnt work, it masks the anxiety when you in non social situations, but you will still get an attack when you put yourself is stressful situations. Obviously you can have therapy but like i said above this will just get you to understand that the cause for your anxiety is YOU.

      All i can say is what worked for me and that is a process called mindfulness, many an article to search for on the internet, also ( although she is as funny as cramp ) Ruby Wax's book is a very good read on the subject.

      good luck dont give up hope.
      Roddenberry
      • LFC Reds Subscriber
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      • 15,749 posts | 1460 
      Re: The Medical Thread.
      Reply #67: Jun 06, 2015 12:01:47 am
      Any one with some tips about dealing with a concussion?  Feel nauseous but not like I'm going to throw up, feel tired but not sleepy, stand up and the world moves around me.  In the last couple of hours, my neck's been sore as hell, nothing seems to ease it.  Typing this out was a pain as well, got a touch of light sensitivity and can't focus properly.
      HScRed1
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      Re: The Medical Thread.
      Reply #68: Jun 06, 2015 12:04:51 am
      Any one with some tips about dealing with a concussion?  Feel nauseous but not like I'm going to throw up, feel tired but not sleepy, stand up and the world moves around me.  In the last couple of hours, my neck's been sore as hell, nothing seems to ease it.  Typing this out was a pain as well, got a touch of light sensitivity and can't focus properly.

      Get your self to A/E you silly fool.

      Your symptoms sound like a migraine FWIW.
      KopiteLuke
      • Forum Legend - Shankly
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      • 21,056 posts | 3784 
      Re: The Medical Thread.
      Reply #69: Jun 06, 2015 12:12:01 am
      Any one with some tips about dealing with a concussion?  Feel nauseous but not like I'm going to throw up, feel tired but not sleepy, stand up and the world moves around me.  In the last couple of hours, my neck's been sore as hell, nothing seems to ease it.  Typing this out was a pain as well, got a touch of light sensitivity and can't focus properly.

      https://www.headway.org.uk/minor-head-injury-and-concussion.aspx?gclid=CKXWhbbW-cUCFWPnwgodPiYAJQ

      Probably follow the advice here mate.
      Roddenberry
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      • 15,749 posts | 1460 
      Re: The Medical Thread.
      Reply #70: Jun 06, 2015 12:13:25 am
      Get your self to A/E you silly fool.

      Your symptoms sound like a migraine FWIW.


      Already been & diagnosed, huge bump on the head to prove it. I'm just feeling like sh*t right now, hoping someone had some tips.
      BKLFC
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      Re: The Medical Thread.
      Reply #71: Sep 09, 2016 06:11:32 pm
      Hi everybody!
      Sorry to restart this thread after so long.
      But I just felt that I needed to inform all me and my wife's update.
      I did not get any recurrence yet after my parotidectomy. But over the years the remnant gland did atrophy. Had a root canal done same side which I attribute to less saliva. Never did put a cap on the tooth. What's the point after you killed the tooth, right?
      Me and Missus tried again in the IVF clinic with our last set of frozen embryos. The 15 day wait till the Beta HCG test was all that was needed, didn't even come up positive. More disappointment and crying and heading back home.
      Our only option now, to us seemed like surgery with an experienced surgeon.
      A month passed after returning from the birth clinic and the Endometerosis pain returned. Wife was now pressing for a quicker surgery date.
      But I had already realised that postponing the surgery and getting her to lose weight (she put on weight due to pain meds, inactive lifestyle due to pain, lupron and the IVF meds) would be a better way to make sure of a higher chance of surgery success rate.
      She had already started eating more healthy food and stopped junk foods. Added hemp seeds to her diet. And to lose weight ate 9 lemons first thing in the morning. Suprise surprise by the 2nd month she had lost 8 kegs. Added Lugols Iodine 2 drops to a glass of juice to give her thyroid the oomph needed to absorb all the trace minerals.
      The pain still returned 2 month but for shorter durations, still very excruciating pain.
      I learned the lymphatic massage and Mayan massage.
      Than the 3rd month her period dosent arrive. Voila! A Miracle. The home kit came strong positive first time. Heard the heart beat as well through a TVS scan and going to hospital in Kathmandu.
      Feel very happy!
      Thanks all for your time and interest and wish all of you good health and for those on the down, happy healing!
      YNWA
      MsGerrard
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      Re: The Medical Thread.
      Reply #72: Sep 09, 2016 06:32:07 pm
      ^^^ All the very best to you and your Wife, hope everything turns out well for you both  :)
      BKLFC
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      Re: The Medical Thread.
      Reply #73: Sep 09, 2016 06:42:11 pm
      Thanks for your well wishes MsG will need every bit of it till successful delivery. Oh me Nerves!
      MsGerrard
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      Re: The Medical Thread.
      Reply #74: Sep 09, 2016 07:13:01 pm
      Thanks for your well wishes MsG will need every bit of it till successful delivery. Oh me Nerves!

      My pleasure...when's the due date?
      BKLFC
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      Re: The Medical Thread.
      Reply #75: Sep 11, 2016 07:41:14 am
      We are only midway through the 2nd trimester, so don't know the expected date yet!
      The Kopite91
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      Re: The Medical Thread.
      Reply #76: Sep 11, 2016 08:16:52 pm
      I recently got kicked by a horse (occupational hazard) into my right side under my ribs, above my hip, no bones broken luckily. I had a slight bleed in my kidney and had a night in hospital for observation. It was sore but far from excruciating, I took a few days off work and went back (admittedly too soon). There was slight muscle damage and deep internal bruising, and through the ins and outs of the job I aggrevated the muscle injury and at the same time suffered from some bad muscle spasms. Another few days off plus some muscle relaxers and pain killers. I am generally fine now, but it will be a month since the incident and I still suffer from pain from my side, mainly at rest, I am fine when I'm up and moving. I'm finding myself falling asleep in the same position each night just to accommodate the pain. It's been going on for a while obviously and I'm not a fan of pills so I've weaned myself off the pain killers.

      I am usually very good at understanding my own body and my own healing time. I'm not Macho man rushing things, saying I'm fine when I'm not, but I know the initial injury wasn't bad. But I feel like I should be over this by now. Has anyone had anything similar? Or have any ideas?
      Roddenberry
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      Re: The Medical Thread.
      Reply #77: Sep 11, 2016 08:27:17 pm
      Ribs and the lattice of interconnecting muscle and tissue around them are a bi*ch. 5 weeks after my bike accident, everything else if fine,  but not my ribs and certain movements, especially sideways ones. I don't like taking the painkillers either, refused them at hospital, which was a mistake.
       
      The Kopite91
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      Re: The Medical Thread.
      Reply #78: Sep 11, 2016 08:48:53 pm
      Ribs and the lattice of interconnecting muscle and tissue around them are a bi*ch. 5 weeks after my bike accident, everything else if fine,  but not my ribs and certain movements, especially sideways ones. I don't like taking the painkillers either, refused them at hospital, which was a mistake.
       

      You've hit the nail on the head mate... summed me up perfectly! Did you find anything to help you along or is it a case of let time sort it?
      Roddenberry
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      Re: The Medical Thread.
      Reply #79: Sep 11, 2016 08:52:33 pm
      You've hit the nail on the head mate... summed me up perfectly! Did you find anything to help you along or is it a case of let time sort it?

      Time I'm afraid, nothing else for it.
      The Kopite91
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      Re: The Medical Thread.
      Reply #80: Sep 11, 2016 08:56:04 pm
      Time I'm afraid, nothing else for it.

      Thanks Rodders, just needed some reassurance. Like I say I'm usually very good at judging these things but this has me quite frustrated.
      Roddenberry
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      Re: The Medical Thread.
      Reply #81: Sep 11, 2016 08:58:43 pm
      Thanks Rodders, just needed some reassurance. Like I say I'm usually very good at judging these things but this has me quite frustrated.

      I once flexed the cartilage in by rib cage, that took three-four months to heal. I'm hoping this is quicker.
      The Kopite91
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      Re: The Medical Thread.
      Reply #82: Sep 11, 2016 09:00:45 pm
      I once flexed the cartilage in by rib cage, that took three-four months to heal. I'm hoping this is quicker.

      F***ing hell mate, hope all is ok with you now!?
      Roddenberry
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      Re: The Medical Thread.
      Reply #83: Sep 11, 2016 09:09:25 pm
      F***ing hell mate, hope all is ok with you now!?

      This time I cycled in to a cement truck, dented it with my head. Also fu**ed up my bike, nearly as bad as my ribs.
      The Kopite91
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      Re: The Medical Thread.
      Reply #84: Sep 11, 2016 09:19:01 pm
      This time I cycled in to a cement truck, dented it with my head. Also fu**ed up my bike, nearly as bad as my ribs.

      There's a joke in there somewhere but now isn't the time! :P

      Genuinely hope you're as well as you can be after something like that mate.
      Roddenberry
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      Re: The Medical Thread.
      Reply #85: Sep 11, 2016 09:27:46 pm
      There's a joke in there somewhere but now isn't the time! :P

      Genuinely hope you're as well as you can be after something like that mate.

      Apart from the ribs and some side effects from my second concussion in eight months, I'm well. You keep safe as well, though better a horse kick than a donkey punch.
      The Kopite91
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      Re: The Medical Thread.
      Reply #86: Sep 11, 2016 09:32:43 pm
      Apart from the ribs and some side effects from my second concussion in eight months, I'm well. You keep safe as well, though better a horse kick thn a donkey punch.

      Haha I'll take a horse kick any day! :D
      LFCexiled
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      Re: The Medical Thread.
      Reply #87: Jul 09, 2017 03:04:07 pm
      Got back from A&E about an hour ago, parasol broke in the wind so I had to drill a stud out of one of the struts, drill slipped off the stud and the drill bit entered the old hand.

      It did smart a bit I tells ya. 😲😯
      MsGerrard
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      Re: The Medical Thread.
      Reply #88: Jul 09, 2017 08:25:31 pm
      Got back from A&E about an hour ago, parasol broke in the wind so I had to drill a stud out of one of the struts, drill slipped off the stud and the drill bit entered the old hand.

      It did smart a bit I tells ya. 😲😯

      Ouch !!! I can imagine you said a few choice words at the time Ian  :holyshit:
      LFCexiled
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      Re: The Medical Thread.
      Reply #89: Jul 11, 2017 08:38:01 am
      Ouch !!! I can imagine you said a few choice words at the time Ian  :holyshit:

      I couldn't, I was in the garden and the kids were there. Little shits. ;D

      It was the quietest injury I've had, i went in the house and dressed it and when Sam told our oldest lily she said "I never heard any drama", cheeky little mare.
      MsGerrard
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      Re: The Medical Thread.
      Reply #90: Jul 11, 2017 09:24:52 am
      I couldn't, I was in the garden and the kids were there. Little shits. ;D

      It was the quietest injury I've had, i went in the house and dressed it and when Sam told our oldest lily she said "I never heard any drama", cheeky little mare.

      Ha ha ha...kids eh !!
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      Re: The Medical Thread.
      Reply #91: Jul 23, 2017 06:21:55 am
      Oh my f**king god!! Had a slight bit of toothache through the week but was nothing pain really, went pretty quick. Yesterday though, unless I'm up and doing something it's f**king agony beyond belief!!! Barely slept and the pain is literally near on unbearable!! Never felt pain like it!
      MsGerrard
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      Re: The Medical Thread.
      Reply #92: Jul 23, 2017 01:43:00 pm
      Oh my f**king god!! Had a slight bit of toothache through the week but was nothing pain really, went pretty quick. Yesterday though, unless I'm up and doing something it's f**king agony beyond belief!!! Barely slept and the pain is literally near on unbearable!! Never felt pain like it!

      Toothache is one of the most painful things in the world, I'd sooner give birth anyday  :laugh: Get yourself to the dentist asap Ben....rid yourself of the nightmare  >:(
      FATKOPITE10
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      Re: The Medical Thread.
      Reply #93: Jul 23, 2017 01:53:03 pm
      Oh my f**king god!! Had a slight bit of toothache through the week but was nothing pain really, went pretty quick. Yesterday though, unless I'm up and doing something it's f**king agony beyond belief!!! Barely slept and the pain is literally near on unbearable!! Never felt pain like it!

      Do it ASAP,  i left it too long and ended up in agony and i was in tears at times with the pain and ended up having seven teeth out in two sittings
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      Re: The Medical Thread.
      Reply #94: Jul 24, 2017 05:07:54 pm
      Had an emergency appointment today and had the start of a root canal done. Was inflamed and infected so it's got some antibiotic thing and a temp filling or something and now have 2x 1 hour appointments for the the rest of it. Still hurts a bit but that could be a mixture of where the infection was, having the work done today I guess. As it goes was actually pain free last night, but today it was one tooth untouchable instead of pain along the gum like before, must have been coming off of that tooth the other day or something.

      Tell you what though, I've had broken bones and torn ligaments that have been less painful that the other day!
      HUYTON RED
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      Re: The Medical Thread.
      Reply #95: Jul 30, 2017 04:43:24 am
      Currently suffering with Psoriasis in two spots, around one of my elbows and slighty on arm and just above ankle.

      Cream on to try and take away itching feeling, but painful like a motherfucker!!
      LFCexiled
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      Re: The Medical Thread.
      Reply #96: Aug 11, 2017 06:51:51 pm
      In for an operation at 7.45am tomorrow to repair a torn frenulum. (Enjoy that thought gents)

      F***ing coutinho, ya pr**k.

      ;D

      I'm hoping I'm first in so I can be back for kick off, not holding out much hope tbh.
      Frankly, Mr Shankly
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      Re: The Medical Thread.
      Reply #97: Aug 11, 2017 07:16:23 pm
      In for an operation at 7.45am tomorrow to repair a torn frenulum. (Enjoy that thought gents)

      F***ing coutinho, ya pr**k.

      ;D

      I'm hoping I'm first in so I can be back for kick off, not holding out much hope tbh.

      Errr...as in your banjo string? And you tore it off when you read that Coutinho had handed in a transfer request? And more to the point - ouch!
      LFCexiled
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      Re: The Medical Thread.
      Reply #98: Aug 11, 2017 07:38:35 pm
      Errr...as in your banjo string? And you tore it off when you read that Coutinho had handed in a transfer request? And more to the point - ouch!

      Yup banjo, nope, but everything's Phil's fault (unless you blame the owners of course) and yes ouch.

      Cut, snip, cut, sew.

      I'm back in work on Monday so I'm hoping it'll be foine.

      😏

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      Re: The Medical Thread.
      Reply #99: Aug 11, 2017 08:40:05 pm
      Yup banjo, nope, but everything's Phil's fault (unless you blame the owners of course) and yes ouch.

      Cut, snip, cut, sew.

      I'm back in work on Monday so I'm hoping it'll be foine.

      😏



      Well it seems like a standard procedure so I'm sure all will go well. Makes my eyes water though...
      KopiteLuke
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      Re: The Medical Thread.
      Reply #100: Aug 11, 2017 09:41:43 pm
      In for an operation at 7.45am tomorrow to repair a torn frenulum. (Enjoy that thought gents)

      F***ing coutinho, ya pr**k.

      ;D

      I'm hoping I'm first in so I can be back for kick off, not holding out much hope tbh.

      My eyes are watering at the thought of that!

      Good luck.
      HScRed1
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      Re: The Medical Thread.
      Reply #101: Aug 12, 2017 12:51:42 am
      In for an operation at 7.45am tomorrow to repair a torn frenulum. (Enjoy that thought gents)

      F***ing coutinho, ya pr**k.

      ;D

      I'm hoping I'm first in so I can be back for kick off, not holding out much hope tbh.

      What a beast   :D

      All the best mate.

      zz19a
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      Re: The Medical Thread.
      Reply #102: Aug 12, 2017 12:59:44 am
      In for an operation at 7.45am tomorrow to repair a torn frenulum. (Enjoy that thought gents)

      F***ing coutinho, ya pr**k.

      ;D

      I'm hoping I'm first in so I can be back for kick off, not holding out much hope tbh.

      All the best.  YNWA
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      Re: The Medical Thread.
      Reply #103: Aug 12, 2017 07:49:35 am
      Cheers lads.

      I'm going in!

      😱

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      Re: The Medical Thread.
      Reply #104: Aug 12, 2017 09:40:07 am

      All the best mate, it'll be kosher once done :)
      LFCexiled
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      Re: The Medical Thread.
      Reply #105: Aug 12, 2017 09:47:10 am
      All the best mate, it'll be kosher once done :)

      If only, the aneasthatist called it off because I've got a cough. It's the second time I've been all gowned up ready to go and it's been cancelled, the first time the surgeon had to go and do an emergency op at the hospital which was fair enough.

      Ah well, cocks all still in one piece.
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      Re: The Medical Thread.
      Reply #106: Aug 12, 2017 10:00:09 am
      If only, the aneasthatist called it off because I've got a cough. It's the second time I've been all gowned up ready to go and it's been cancelled, the first time the surgeon had to go and do an emergency op at the hospital which was fair enough.

      Ah well, cocks all still in one piece.

      No NHS cuts today then?

      What's the pain like? 

      When ever I think of penis and coughs though, I do wonder if what the Doctor was doing was legitimate. It wasn't only me was it, getting your vaccination boosters at school, told to drop trou, have you balls fondled and asked to cough? Please don't say it was just me.
      « Last Edit: Aug 12, 2017 10:09:26 am by Roddenberry »
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      Re: The Medical Thread.
      Reply #107: Aug 12, 2017 10:04:01 am
      No NHS cuts today then?

      What's the pain like? 

      When ever I think of penis and coughs though, I do wonder if what the Doctor doing was legitimate. It wasn't only me was it, getting your vaccination boosters at school, told to drop trou, have you balls fondled and asked to cough? Please don't say it was just me.

      Deffo no NHS cuts, it was a private hospital, I don't mix with you rough types.

      It was being paid for by the wonderful NHS though.  ;)

      As regards the other stuff, not just you mate, our school nurse was called Uncle Jimmy. I remember he had white hair but the rest's a bit vague, I always remember feeling a bit sleepy around uncle Jimmy.
      Roddenberry
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      Re: The Medical Thread.
      Reply #108: Aug 12, 2017 10:08:31 am

      Did he fix it for you?
      LFCexiled
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      Re: The Medical Thread.
      Reply #109: Aug 12, 2017 10:30:28 am

      Well, not for most ailments but he was very good at his specialty, constipation.
      Shabs
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      Re: The Medical Thread.
      Reply #110: Aug 12, 2017 11:27:03 am

      If only, the aneasthatist called it off because I've got a cough. It's the second time I've been all gowned up ready to go and it's been cancelled, the first time the surgeon had to go and do an emergency op at the hospital which was fair enough.

      Ah well, cocks all still in one piece.

      Not meant  to be, take it as a sign :)




      No NHS cuts today then?

      What's the pain like? 

      When ever I think of penis and coughs though, I do wonder if what the Doctor was doing was legitimate. It wasn't only me was it, getting your vaccination boosters at school, told to drop trou, have you balls fondled and asked to cough? Please don't say it was just me.

      Ahh the cough test.. We Had it at school too :)

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