Doesn't look good at all. Jürgen said "I don't know how long that will take". I follow Jürgen for almost 20 years, back where he worked in Mainz. And that phrase usually meant several weeks at least, including a chance that it is worse. Usually when it's a 1-2 week-thing Jürgen says something along the lines "it's not big, he's close, but not today", when it's day-to-day he basically says that the player looks fine and is an option.
This one game vs. Everton was a gamechanger. It's worse than when City lost KDB two seasons ago. But you could read between the lines of Jürgen's PC that he will motivate his team thru the VVD-VAR-incident. That could be a blessing in disguise.